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专注于生物学试剂及试剂盒领域
服务热线：18101056239
产品型号：K200045M
更新时间：2022-08-15
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Anti-NFKB p65 Monoclonal Antibody
| 英文名称 | Anti-NFKB p65 Monoclonal Antibody |
|---|---|
| 宿主 | Mouse |
| 别名 | MGC131774;NFKB 3;NFKB3;TF65_HUMAN |
| 应用 | WB IHC IP |
| 稀释比例 | WB 1:1000-3000. IP 1:100-300. IF 1:100-200. IHC 1:200-500. |
| 蛋白分子量 | 65kDa |
| Gene ID | 5970 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG1 |
| 免疫原 | recombinant protein |
| 性状 | 液体 |
| Public Immunogen Range | recombinant protein |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q04206 |
| 克隆号 | 5G6 |
| 克隆类型 | Monoclonal Antibody |
| 背景资料 | NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection. |
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