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  • 一抗-多抗 Rabbit Anti-API5 antibody凋亡抑制因子5抗体
产品名称：

一抗-多抗 Rabbit Anti-API5 antibody凋亡抑制因子5抗体
产品品牌： SOLARBIO/索莱宝 价格：
厂商性质： 生产厂家 产品时间： 2024-03-24
一抗-多抗 Rabbit Anti-API5 antibody凋亡抑制因子5抗体
货号：bs-1252R
规格：0.1ml/0.2ml
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
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产品概述

品牌SOLARBIO/索莱宝

 一抗-多抗 Rabbit Anti-API5 antibody凋亡抑制因子5抗体

产品编号bs-1252R
英文名称API5
中文名称凋亡抑制因子5抗体
别    名apoptosis inhibitor 5; apoptosis inhibitory protein 5; API5; AAC-11; AAC11; API5L1; AAC 11; Antiapoptosis clone 11 protein; API5 like 1; Cell migration inducing gene 8 protein; Fibroblast growth factor 2 interacting factor 2; FIF; Migration inducing protein MIG8; MIG 8; MIG8; Protein XAGL; API5_HUMAN.
研究领域肿瘤  免疫学  细胞凋亡  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig, 
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
细胞定位细胞核 细胞浆 
性    状Lyophilized or Liquid111
浓    度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human API5
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
生 产 商BIOSS
PubMedPubMed
产品介绍background:
Apoptosis inhibitor 5 (API5) is an antiapoptotic factor which may have a role in protein assembly. API5 expression is often upregulated in tumor cells, particularly in metastatic cells. It is a critical determinant of E2F1-induced apoptosis, acting downstream of E2F to suppress E2F-dependent apoptosis without generally blocking E2F-dependent transcription. Alternate Names: AAC 11; AAC11; Antiapoptosis clone 11 protein; API 5; API5; API5 like 1; API5L1; Cell migration inducing gene 8 protein; Fibroblast growth factor 2 interacting factor 2; FIF; MIG 8; MIG8; Migration inducing protein MIG8; Protein XAGL.

Function:
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.

Subunit:
Monomer. Interacts with FGF2 and ACIN1.

Subcellular Location:
Nucleus. Cytoplasm. Note=Mainly nuclear. Can also be cytoplasmic. 
Isoform 3: Cytoplasm.

Tissue Specificity:
Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer.

Post-translational modifications:
Acetylation at Lys-251 impairs antiapoptotic function.

Similarity:
Belongs to the API5 family.

Gene ID:
8539

Database links:

Entrez Gene: 8539 Human

Entrez Gene: 11800 Mouse

Omim: 609774 Human

SwissProt: Q9BZZ5 Human

SwissProt: O35841 Mouse

Unigene: 435771 Human

Unigene: 181824 Mouse

Unigene: 402557 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

IAP-5是细胞凋亡的一种抑制因子、参与细胞凋亡调控，可以用于各种恶性肿瘤的细胞凋亡的研究.
产品图片

Antigen: bs-1252P, 0.2ug/100ul 
Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; 
Secondary: HRP conjugated Goat Anti-Rabbit IgG(bs-0295G-HRP) at 1: 5000; 
TMB(C-0024) staining; 
Read the data in MicroplateReader by 450nm. 

Protein: mouse heart lysates(A); mouse pancreas lysates(B); 
Primary: Anti-API5 (bs-1252R) at 1:300; 
Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bse-0295G-HRP) at 1: 5000; 
ECL excitated the fluorescence; 
Predicted band size : 57 kD
Observed band size :57 kD

每一种抗体可以分别标记20种不同的标记物：

Alexa Fluor 350 APCCy7 HRP
Alexa Fluor 488Biotin FITC PE 
Alexa Fluor 555 Cy3 Gold RBITC
Alexa Fluor 647 Cy5.5  PE-Cy3PE-CY7
AP Cy5 PE-CY5PE-CY5.5 

一抗-多抗 Rabbit Anti-API5 antibody凋亡抑制因子5抗体订购说明：

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