Anti-PARP Monoclonal Antibody
应用 WB IHC
稀释比例WB 1:1000-3000. IHC 1:200-500.
交叉反应Human

产品型号：K200026M

更新时间：2022-08-15

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Anti-PARP Monoclonal Antibody

英文名称	Anti-PARP Monoclonal Antibody
宿主	Mouse
别名	PARP-1; Poly(ADP ribose) polymerase 1; sPARP1;ADPRT1; ADP ribosyltransferase NAD(+)
应用	WB IHC
稀释比例	WB 1:1000-3000. IHC 1:200-500.
交叉反应	Human
蛋白分子量	116kDa
Gene ID	142
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG1
免疫原	A synthetic peptide coupled to KLH
性状	液体
Public Immunogen Range	A synthetic peptide coupled to KLH
Subcellular Locations	Nucleus
Swiss Prot	P09874
克隆号	M3
克隆类型	Monoclonal Antibody
背景资料	Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate.