北京索莱宝科技
专注于生物学试剂及试剂盒领域
服务热线：18101056239
专注于生物学试剂及试剂盒领域
服务热线：18101056239
产品型号：K101291P
更新时间：2022-08-15
厂商性质：生产厂家
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Anti-CASP3 Polyclonal Antibody
| 英文名称 | Anti-CASP3 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CPP32;CPP32B;SCA-1;SREBP cleavage activity 1;Cysteine protease CPP32 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:80. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 31kDa |
| Gene ID | 836 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human CASP3 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human CASP3 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P42574 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. |
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