北京索莱宝科技
专注于生物学试剂及试剂盒领域
服务热线：18101056239
专注于生物学试剂及试剂盒领域
服务热线：18101056239
产品型号：K101533P
更新时间：2022-08-15
厂商性质：生产厂家
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| 英文名称 | Anti-CD14 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CD14;Monocyte differentiation antigen CD14;CD14 molecule;LPS-R;Mo2 |
| 应用 | WB |
| 稀释比例 | WB 1:3000. |
| 交叉反应 | Human |
| 蛋白分子量 | 40kDa |
| Gene ID | 929 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human CD14 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human CD14 |
| Subcellular Locations | Cell membrane GPI-anchor Lipid-anchor Secreted |
| Swiss Prot | P08571 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. |
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