北京索莱宝科技
专注于生物学试剂及试剂盒领域
服务热线：18101056239
专注于生物学试剂及试剂盒领域
服务热线：18101056239
产品型号：K106402P
更新时间：2022-08-15
厂商性质：生产厂家
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产品分类
Anti-CD8 Polyclonal Antibody
| 英文名称 | Anti-CD8 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CD8A;MAL;Leu2;p32;OKT8 T cell antigen |
| 应用 | WB |
| 稀释比例 | WB 1:3000. |
| 交叉反应 | Mouse |
| 蛋白分子量 | 28kDa |
| Gene ID | 925 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human CD8 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human CD8 |
| Subcellular Locations | Cell membrane |
| Swiss Prot | P01732 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. |
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