北京索莱宝科技
专注于生物学试剂及试剂盒领域
服务热线：18101056239
专注于生物学试剂及试剂盒领域
服务热线：18101056239
产品型号：K106409P
更新时间：2022-08-15
厂商性质：生产厂家
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产品分类
Anti-AIFM1 Polyclonal Antibody
| 英文名称 | Anti-AIFM1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AIF;PDCD8;CMT2D;CMTX4;COWCK;COXPD6;DFNX5;NADMR;NAMSD |
| 应用 | WB |
| 稀释比例 | WB 1:3000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 67kDa |
| Gene ID | 9131 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human AIFM1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human AIFM1 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | O95831 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. |
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