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  • Anti-AIFM1 Polyclonal Antibody
产品名称:

Anti-AIFM1 Polyclonal Antibody

产品品牌: 索莱宝 价格: 960
厂商性质: 生产厂家 产品时间: 2022-08-15
Anti-AIFM1 Polyclonal Antibody
应用 WB
稀释比例WB 1:3000.
交叉反应Human Mouse Rat

产品概述

品牌SOLARBIO/索莱宝货号K106409P
规格50ul/100ul供货周期现货
主要用途WB应用领域医疗卫生,环保,化工,生物产业,农业

Anti-AIFM1 Polyclonal Antibody

英文名称Anti-AIFM1 Polyclonal Antibody
宿主Rabbit
别名AIF;PDCD8;CMT2D;CMTX4;COWCK;COXPD6;DFNX5;NADMR;NAMSD
应用WB
稀释比例WB 1:3000.
交叉反应Human Mouse Rat
蛋白分子量67kDa
Gene ID9131
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原A synthetic peptide of human AIFM1
性状液体
Public Immunogen RangeA synthetic peptide of human AIFM1
Subcellular LocationsCytoplasm Nucleus
Swiss ProtO95831
克隆类型Polyclonal Antibody
背景资料Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.

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