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您的位置: 网站首页 > 产品中心 > 抗体 > Polyclonal Antibody > K106454PAnti-ERK1 Polyclonal Antibody
  • Anti-ERK1 Polyclonal Antibody
  • Anti-ERK1 Polyclonal Antibody
  • Anti-ERK1 Polyclonal Antibody
  • Anti-ERK1 Polyclonal Antibody
产品名称:

Anti-ERK1 Polyclonal Antibody

产品品牌: 索莱宝 价格: 960
厂商性质: 生产厂家 产品时间: 2022-08-15
Anti-ERK1 Polyclonal Antibody
应用 WB IHC
稀释比例WB 1:2000-5000.IHC 1:50-200.
交叉反应 Human Mouse Rat

产品概述

品牌SOLARBIO/索莱宝货号K106454P
规格50ul/100ul供货周期现货
主要用途WB IHC应用领域医疗卫生,环保,化工,生物产业,农业

Anti-ERK1 Polyclonal Antibody

英文名称Anti-ERK1 Polyclonal Antibody
宿主Rabbit
别名MAPK 3;p44-MAPK;p44-ERK1;PRKM3;MAPK3
应用WB IHC
稀释比例WB 1:2000-5000.IHC 1:50-200.
蛋白分子量43kDa
Gene ID5594/5595
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原A synthetic peptide of human ERK1
性状液体
Public Immunogen RangeA synthetic peptide of human ERK1
Subcellular LocationsCytoplasm Nucleus
Swiss ProtP27361
克隆类型Polyclonal Antibody
背景资料Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.

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