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  • Anti-APP Polyclonal Antibody
产品名称:

Anti-APP Polyclonal Antibody

产品品牌: 索莱宝 价格:
厂商性质: 生产厂家 产品时间: 2022-08-15
Anti-APP Polyclonal Antibody
应用 WB
稀释比例WB 1:3000.
交叉反应Human Mouse Rat

产品概述

品牌SOLARBIO/索莱宝货号K106430P
规格50ul/100ul供货周期现货
主要用途WB应用领域医疗卫生,环保,化工,生物产业,农业

Anti-APP Polyclonal Antibody

英文名称Anti-APP Polyclonal Antibody
宿主Rabbit
别名AAA;ABETA;ABPP;AD1;APPI;CTFgamma;CVAP;PN-II;PN2;preA4
应用WB
稀释比例WB 1:3000.
交叉反应Human Mouse Rat
蛋白分子量120kDa
Gene ID351
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原A synthetic peptide of human APP
性状液体
Public Immunogen RangeA synthetic peptide of human APP
Subcellular LocationsAmyloid Coated pit Membrane
Swiss ProtP05067
克隆类型Polyclonal Antibody
背景资料Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu2+-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu2+ ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.

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