北京索莱宝科技
专注于生物学试剂及试剂盒领域
服务热线：18101056239
专注于生物学试剂及试剂盒领域
服务热线：18101056239
产品型号：K106457P
更新时间：2022-08-15
厂商性质：生产厂家
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产品分类
Anti-c-fos Polyclonal Antibody
| 英文名称 | Anti-c-fos Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | FOS;G0S7;AP-1;p55 |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 53kDa |
| Gene ID | 2353 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human c-fos |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human c-fos |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P01100 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum |
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