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  • Anti-AKT1+2+3 Polyclonal Antibody
产品名称:

Anti-AKT1+2+3 Polyclonal Antibody

产品品牌: 索莱宝 价格: 960
厂商性质: 生产厂家 产品时间: 2022-08-15
Anti-AKT1+2+3 Polyclonal Antibody
应用 WB
稀释比例WB 1:3000.
交叉反应Human Mouse Rat

产品概述

品牌SOLARBIO/索莱宝货号K106557P
规格50ul/100ul供货周期现货
主要用途WB应用领域医疗卫生,环保,化工,生物产业,农业

Anti-AKT1+2+3 Polyclonal Antibody

英文名称Anti-AKT1+2+3 Polyclonal Antibody
宿主Rabbit
别名AKT;CWS6;PKB;PKB-ALPHA;PRKBA;RAC;RAC-ALPHA
应用WB
稀释比例WB 1:3000.
交叉反应Human Mouse Rat
蛋白分子量65kDa
Gene ID207
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原A synthetic peptide of human AKT1+2+3
性状液体
Public Immunogen RangeA synthetic peptide of human AKT1+2+3
Subcellular LocationsCell membrane Cytoplasm Nucleus
Swiss ProtP31749
克隆类型Polyclonal Antibody
背景资料The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

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