北京索莱宝科技
专注于生物学试剂及试剂盒领域
服务热线：18101056239
专注于生物学试剂及试剂盒领域
服务热线：18101056239
产品型号：K106589P
更新时间：2022-08-15
厂商性质：生产厂家
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产品分类
Anti-ERK1/2 Polyclonal Antibody
| 英文名称 | Anti-ERK1/2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ERK;ERK-2;MAPK2;p38;p40;p41;p41mapk;p42-MAPK;P42MAPK;PRKM1;PRKM2 |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 41kDa |
| Gene ID | 5594 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ERK1/2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ERK1/2 |
| Subcellular Locations | Cytoplasm Nucleus Cell membrane Cytoskeleton |
| Swiss Prot | P28482 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. |
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