Anti-TERT Polyclonal Antibody

英文名称	Anti-TERT Polyclonal Antibody
宿主	Rabbit
别名	EST2;TCS1;TRT;HEST2;TP2
应用	IHC
稀释比例	IHC 1:50-200.
交叉反应	Mouse
蛋白分子量	127kDa
Gene ID	7015
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	A synthetic peptide of human TERT
性状	液体
Public Immunogen Range	A synthetic peptide of human TERT
Subcellular Locations	Cytoplasm
Swiss Prot	O14746
克隆类型	Polyclonal Antibody
背景资料	Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats.