北京索莱宝科技有限公司
专注于生物学试剂及试剂盒领域
服务热线：18101056239
专注于生物学试剂及试剂盒领域
服务热线：18101056239
产品型号：K106624P
更新时间：2022-08-15
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Anti-BAX Polyclonal Antibody
| 英文名称 | Anti-BAX Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | Bcl2-L-4;Bax-protein;BAX_HUMAN;BAXA |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 21kDa |
| Gene ID | 581 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human BAX |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human BAX |
| Subcellular Locations | Cytoplasm Cell membrane |
| Swiss Prot | Q07812 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.7 |
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