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  • Anti-CIP2A Polyclonal Antibody
产品名称:

Anti-CIP2A Polyclonal Antibody

产品品牌: 索莱宝 价格: 960
厂商性质: 生产厂家 产品时间: 2022-08-15
Anti-CIP2A Polyclonal Antibody
应用 WB
稀释比例WB 1:500-2000.
交叉反应Human

产品概述

品牌SOLARBIO/索莱宝货号K106617P
规格50ul/100ul供货周期现货
主要用途WB应用领域医疗卫生,环保,化工,生物产业,农业

Anti-CIP2A Polyclonal Antibody

英文名称Anti-CIP2A Polyclonal Antibody
宿主Rabbit
别名CIP2A;KIAA1524;Protein CIP2A;p90
应用WB
稀释比例WB 1:500-2000.
交叉反应Human
蛋白分子量102kd
Gene ID57650
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原Recombinant protein of human CIP2A
性状液体
Public Immunogen RangeRecombinant protein of human CIP2A
Subcellular LocationsCytoplasm Cell membrane
Swiss ProtQ8TCG1
克隆类型Polyclonal Antibody
背景资料Cancerous inhibitor of protein phosphatase 2A (CIP2A), also designated p90 autoantigen or KIAA1524, is a single-pass membrane protein that exhibits oncogenic activity. CIP2A is known to inhibit PP2A (protein phosphatase 2A) dephosphorylation of c-Myc, thereby stabilizing c-Myc (an oncogenic transcription factor) and promoting tumor formation and malignant cell growth. PP2A is a trimeric protein complex consisting of three subunits: a scaffold subunit, a catalytic subunit and a regulatory subunit. CIP2A specifically interacts with the catalytic subunit of PP2A to inhibit its activity. Inhibition of PP2A activity is a crucial step allowing for the progression of human cell transformation. Further supporting its role as an oncoprotein, CIP2A is known to be overexpressed in colon, gastric, and head and neck squamous cell carcinomas.

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