北京索莱宝科技
专注于生物学试剂及试剂盒领域
服务热线：18101056239
专注于生物学试剂及试剂盒领域
服务热线：18101056239
产品型号：K106646P
更新时间：2022-08-15
厂商性质：生产厂家
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产品分类
Anti-MADH7 Polyclonal Antibody
| 英文名称 | Anti-MADH7 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CRCS3;MADH7;MADH8;Hsmad7；MAD homolog 8 |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 46kDa |
| Gene ID | 4092 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human MADH7 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human MADH7 |
| Subcellular Locations | Nucleus |
| Swiss Prot | O15105 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R1-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
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