北京索莱宝科技
专注于生物学试剂及试剂盒领域
服务热线：18101056239
专注于生物学试剂及试剂盒领域
服务热线：18101056239
产品型号：K106765P
更新时间：2022-08-14
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Anti-GADD153 Polyclonal Antibody
| 英文名称 | Anti-GADD153 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CEBPZ;CHOP;CHOP-10;CHOP10;GADD153;C/EBPzeta;DNA damage inducible transcript 3 |
| 应用 | IHC |
| 稀释比例 | IHC 1:25-100. |
| 交叉反应 | Human |
| 蛋白分子量 | 19kDa |
| Gene ID | 1649 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human GADD153 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human GADD153 |
| Subcellular Locations | Nucleus Cytoplasm |
| Swiss Prot | P35638 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. |
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