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  • Anti-RPA2 Polyclonal Antibody
产品名称:

Anti-RPA2 Polyclonal Antibody

产品品牌: 索莱宝 价格:
厂商性质: 生产厂家 产品时间: 2019-09-09
Anti-RPA2 Polyclonal Antibody
应用WB IHC
稀释比例WB 1:5000-8000. IHC 1:50-200.
交叉反应 Human Mouse

产品概述

品牌SOLARBIO/索莱宝货号K107500P
规格50ul/100ul供货周期现货
主要用途WB IHC应用领域医疗卫生,环保,化工,生物产业,农业

Anti-RPA2 Polyclonal Antibody

宿主Rabbit
英文名称Anti-RPA2 Polyclonal Antibody
别名REPA2;RP-A p32;RP-A p34;RPA32;RP-Ap32;RP-Ap34;replication protein A2
应用WB IHC
稀释比例WB 1:5000-8000. IHC 1:50-200.
蛋白分子量29/38kDa
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原A synthetic peptide of human RFA2
Swiss ProtP15927
Subcellular LocationsNucleus Cytoplasm
克隆类型Polyclonal Antibody
背景资料As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.

 

多克隆抗体

       由于多克隆抗体通常包含抗某一抗原的不同表位的抗体,所以,在深固定的样本中也会很好地发挥效应,在石蜡包埋组织切片的染色中,多克隆抗体常选用。根据实验的不同需要,多克隆抗体应用于相应抗原的标记。此外,在农业生产中,多克隆抗体被用于农药残留现场监测;在临床应用中,多克隆抗体主要用于病原物的检测、疾病的诊断及治疗,如作为蛋白类免疫抑制剂用于移植反应和自身免疫病的治疗。

       索莱宝公司创立于2004年是一家拥有大批专业研发人员,专注于生物产品不断完善和创新的公司。我们产品覆盖面广,品质可靠。在优化试剂产品线的同时,经过多年研发经验的积累,也推出了新的抗体产品线。初期,大批科研人员精心设计,齐力设计出好的抗体产品;后期,质检工作者严格的质量把控为我们保驾护航。终,在我们的共同努力之下,带您见证索莱宝公司的又一奇迹。

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