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| 品牌 | SOLARBIO/索莱宝 | 货号 | K200050M |
|---|---|---|---|
| 规格 | 50ul/100ul | 供货周期 | 现货 |
| 主要用途 | WB IF IHC | 应用领域 | 医疗卫生,环保,化工,生物产业,农林牧渔 |
Anti-EGFR Monoclonal Antibody
| 英文名称 | Anti-EGFR Monoclonal Antibody |
|---|---|
| 宿主 | Mouse |
| 别名 | Epidermal growth factor receptor;erbb 1;Receptor tyrosine protein kinase ErbB 1 |
| 应用 | WB IF IHC |
| 稀释比例 | WB 1:500-2000. IF 1:100-200. IHC 1:200-500. |
| 交叉反应 | Human |
| 蛋白分子量 | 170kDa |
| Gene ID | 1956 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG1 |
| 免疫原 | A synthetic peptide coupled to KLH |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide coupled to KLH |
| Subcellular Locations | Nucleus Endosome Plasma membrane Golgi apparatus Endoplasmic reticulum secreted |
| Swiss Prot | P00533 |
| 克隆号 | 1B1 |
| 克隆类型 | Monoclonal Antibody |
| 背景资料 | The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascadesβ-Actin is one of six different actin isoforms that have been identified. The actin molecules found in cells of various species and tissues tend to be very similar in their immunological and physical properties. Therefore, Antibodies against β-Actin are useful as loading controls for Western Blotting. However it should be noted that levels of β-Actin may not be stable in certain cells. For example, expression of β-Actin in adipose tissue is very low and therefore β-Actin should not be used as loading control for these tissues. |
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