Anti-EGFR Monoclonal Antibody
应用 WB IF IHC
稀释比例WB 1:500-2000. IF 1:100-200. IHC 1:200-500.
交叉反应Human

产品型号：K200050M

更新时间：2022-08-15

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抗体

标签抗体血清球蛋白 IgG Polyclonal Antibody Antibody Monoclonal Antibody 一抗内参抗体胶体金标记二抗生物素化二抗 RBITC荧光标记抗体二抗 FITC荧光标记抗体二抗免疫血清二抗纯化抗体二抗 HRP标记二抗免疫球蛋白抗原IgG二抗

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产品介绍

Anti-EGFR Monoclonal Antibody

英文名称	Anti-EGFR Monoclonal Antibody
宿主	Mouse
别名	Epidermal growth factor receptor;erbb 1;Receptor tyrosine protein kinase ErbB 1
应用	WB IF IHC
稀释比例	WB 1:500-2000. IF 1:100-200. IHC 1:200-500.
交叉反应	Human
蛋白分子量	170kDa
Gene ID	1956
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG1
免疫原	A synthetic peptide coupled to KLH
性状	液体
Public Immunogen Range	A synthetic peptide coupled to KLH
Subcellular Locations	Nucleus Endosome Plasma membrane Golgi apparatus Endoplasmic reticulum secreted
Swiss Prot	P00533
克隆号	1B1
克隆类型	Monoclonal Antibody
背景资料	The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascadesβ-Actin is one of six different actin isoforms that have been identified. The actin molecules found in cells of various species and tissues tend to be very similar in their immunological and physical properties. Therefore, Antibodies against β-Actin are useful as loading controls for Western Blotting. However it should be noted that levels of β-Actin may not be stable in certain cells. For example, expression of β-Actin in adipose tissue is very low and therefore β-Actin should not be used as loading control for these tissues.