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  • Anti-PCNA Polyclonal Antibody
产品名称:

Anti-PCNA Polyclonal Antibody

产品品牌: 索莱宝 价格: 960
厂商性质: 生产厂家 产品时间: 2022-08-15
Anti-PCNA Polyclonal Antibody
应用 WB
稀释比例WB 1:500-2000.
交叉反应Human Mouse Rat

产品概述

品牌SOLARBIO/索莱宝货号K101310P
规格50ul/100ul供货周期现货
主要用途WB应用领域医疗卫生,环保,化工,生物产业,农业

Anti-PCNA Polyclonal Antibody

英文名称Anti-PCNA Polyclonal Antibody
宿主Rabbit
别名ATLD2;cb16;Cyclin;HGCN872;MGC8367
应用WB
稀释比例WB 1:500-2000.
交叉反应Human Mouse Rat
蛋白分子量29kDa
Gene ID5111
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原A synthetic peptide of human PCNA
性状液体
Public Immunogen RangeA synthetic peptide of human PCNA
Subcellular LocationsNucleus
Swiss ProtP12004
克隆类型Polyclonal Antibody
背景资料Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.

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