北京索莱宝科技
专注于生物学试剂及试剂盒领域
服务热线：18101056239
专注于生物学试剂及试剂盒领域
服务热线：18101056239
产品型号：K106453P
更新时间：2022-08-15
厂商性质：生产厂家
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产品分类
Anti-PDX1 Polyclonal Antibody
| 英文名称 | Anti-PDX1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | GSF;IDX-1;IPF1;IUF1;MODY4;PAGEN1;PDX-1;STF-1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:2000-5000.IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 48kDa |
| Gene ID | 3651 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human PDX1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human PDX1 |
| Subcellular Locations | Cytoplasm Nucleus cytosol |
| Swiss Prot | P52945 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. |
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