品牌 | SOLARBIO/索莱宝 | 货号 | K106527P |
---|---|---|---|
规格 | 50ul/100ul | 供货周期 | 现货 |
主要用途 | WB | 应用领域 | 医疗卫生,环保,化工,生物产业,农林牧渔 |
Anti-XIAP Polyclonal Antibody
英文名称 | Anti-XIAP Polyclonal Antibody |
---|---|
宿主 | Rabbit |
别名 | API3;BIRC4;hIAP-3;hIAP3;IAP-3;ILP1;MIHA;XLP2 |
应用 | WB |
稀释比例 | WB 1:3000. |
交叉反应 | Human Mouse Rat |
蛋白分子量 | 54kDa |
Gene ID | 331 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 | Affinity purification |
亚型 | IgG |
免疫原 | A synthetic peptide of human XIAP |
性状 | 液体 |
Public Immunogen Range | A synthetic peptide of human XIAP |
Subcellular Locations | Cytoplasm Nucleus |
Swiss Prot | P98170 |
克隆类型 | Polyclonal Antibody |
背景资料 | This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11. |