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  • Anti-GRP78 Polyclonal Antibody
  • Anti-GRP78 Polyclonal Antibody
  • Anti-GRP78 Polyclonal Antibody
产品名称:

Anti-GRP78 Polyclonal Antibody

产品品牌: 索莱宝 价格: 960
厂商性质: 生产厂家 产品时间: 2022-08-15
Anti-GRP78 Polyclonal Antibody
应用 WB IHC
稀释比例WB 1:2000-5000.IHC 1:50-200.
交叉反应Human Mouse Rat

产品概述

品牌SOLARBIO/索莱宝货号K106525P
规格50ul/100ul供货周期现货
主要用途WB IHC应用领域医疗卫生,环保,化工,生物产业,农业

Anti-GRP78 Polyclonal Antibody

英文名称Anti-GRP78 Polyclonal Antibody
宿主Rabbit
别名BIP;GRP78;HEL-S-89n;MIF2
应用WB IHC
稀释比例WB 1:2000-5000.IHC 1:50-200.
交叉反应Human Mouse Rat
蛋白分子量70kDa
Gene ID3309
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原A synthetic peptide of human GRP78
性状液体
Public Immunogen RangeA synthetic peptide of human GRP78
Subcellular LocationsCytoplasm Endoplasmic reticulum lumen Melanosome
Swiss ProtP11021
克隆类型Polyclonal Antibody
背景资料The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

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