北京索莱宝科技
专注于生物学试剂及试剂盒领域
服务热线：18101056239
专注于生物学试剂及试剂盒领域
服务热线：18101056239
产品型号：K106720P
更新时间：2022-08-15
厂商性质：生产厂家
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产品分类
Anti-P27 Polyclonal Antibody
| 英文名称 | Anti-P27 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CDKN1B;CDKN4;KIP1;MEN1B;MEN4;P27;KIP1;P27KIP1 |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 22kDa |
| Gene ID | 1027 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human P27 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human P27 |
| Subcellular Locations | Nucleus |
| Swiss Prot | P46527 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4) |
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