北京索莱宝科技
专注于生物学试剂及试剂盒领域
服务热线：18101056239
专注于生物学试剂及试剂盒领域
服务热线：18101056239
产品型号：K106719P
更新时间：2022-08-15
厂商性质：生产厂家
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产品分类
Anti-CDK4 Polyclonal Antibody
| 英文名称 | Anti-CDK4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CDK4;Cell division protein kinase 4;CMM3;cyclin dependent kinase 4;PSK J3 |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 34kDa |
| Gene ID | 1019 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human CDK4 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human CDK4 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P11802 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. |
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